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Jobs at X-Chem, Inc. (Now Hiring) — 3 open

X-Chem, Inc. logoX-Chem, Inc.

Research Associate, Library Synthesis

Budapest, Central Hungary, Hungary · On-site

Entry level

At X-Chem, it is our mission to leverage the world’s leading drug discovery platform to help create molecules that will improve human health. X-Chem is a leader in small molecule discovery science, providing pharmaceutic…

Skills: Organic Synthesis, DNA-Encoded Chemical Library, High-throughput Reaction Validation, Reaction Optimization, LCMS

X-Chem, Inc. logoX-Chem, Inc.

Group Leader, Discovery Chemistry

Montreal, Quebec, Canada · On-site

Senior+

At X-Chem, it is our mission to leverage the world’s leading drug discovery platform to help create molecules that will improve human health. At X-Chem, we do more than screen compounds. We help you make confident decisi…

Skills: Medicinal Chemistry, Synthetic Chemistry, Hit Generation, Hit-to-Lead, Lead Optimization

X-Chem, Inc. logoX-Chem, Inc.

Chargé.e de groupe, Chimie de la découverte

Montreal, Quebec, Canada · On-site

Senior+

Chez X-Chem, notre mission est de mettre à profit la première plateforme de découverte de médicaments au monde pour aider à créer des molécules qui amélioreront la santé humaine. Chez X-Chem, nous ne nous contentons pas …

Skills: Medicinal Chemistry, Organic Synthesis, Drug Discovery, Team Leadership, Project Management

X-Chem, Inc. logo

Research Associate, Library Synthesis

X-Chem, Inc.

Budapest, Central Hungary, Hungary • On-site

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Entry level

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  • Full-time
  • bachelor degree, postgraduate degree
  • Private Health Insurance, Preventative Health Programs, Personal Wellness Benefits, Flexible Working Hours, Long-term Loyalty Rewards, Language Learning Opportunities
  • Posted 22d ago
  • Apply by Jun 30
  • ~40 hrs/week

Responsibilities

The role focuses on the synthesis and optimization of DNA-encoded chemical libraries (DELs) and high-throughput reaction validation. It involves meticulous record-keeping, reagent ordering, and collaboration with global teams to advance drug discovery projects.

Requirements

Candidates must hold a BS or MS in Chemistry or a related field with 6 months to 2 years of laboratory experience in organic synthesis. Strong organizational skills, attention to detail, and the ability to work in a team environment are essential.

Full job description

At X-Chem, it is our mission to leverage the world’s leading drug discovery platform to help create molecules that will improve human health.  X-Chem is a leader in small molecule discovery science, providing pharmaceutical and biotechnology companies a complete, seamless solution for screening, hit validation, and lead optimization. As pioneers of DNA-encoded chemical library (DEL) technology, the company leverages its market-leading DEL platform to rapidly screen billions of diverse drug-like molecules to discover novel small molecule leads against challenging, high-value therapeutic targets. In house hit-to-lead and lead optimization services driven by AI and physics-based modeling enable clients to progress their compounds directly from hit all the way through to candidate nomination. Our well-proven expertise in medicinal chemistry, custom synthesis, and scale-up process chemistry enables us to support all aspects of drug discovery in a deeply integrated technology-driven platform. 

 

Job Responsibilities

 

    • High-throughput, on-DNA reaction validation
    • Reaction optimization of on-DNA chemistry
    • Library synthesis for DNA-encoded-libraries (DELs)
    • Buffer preparations
    • Reagent and comsumables ordering
    • Document and communicate experimental results clearly, both within the team and in cross-site meetings
    • Ensure high-quality experimental execution, meticulous record keeping, and adherence to laboratory safety standards
    • Collaborate closely with the DEL team and global colleagues to align priorities and advance ongoing projects
    • Contribute to continuous improvement of internal methods, protocols, and workflows

 

 

Essential Qualifications

 

  • Requirements for the position include a BS or MS in Chemistry or related subject
  • 6 months to 2 years of laboratory experience in an industrial or academic setting
  • Experience in organic synthesis in an industrial or academic setting
  • Needs to be well organized and detail oriented
  • Needs to be able to multitask and set prioritizations to meet timelines
  • Needs to have excellent communication skills
  • Needs to be meticulous with their documentation and data handling
  • Needs to be able to work in a team environment

 

 

Preferred Qualifications

 

  • Working familiarity with LCMS is highly valuable
  • The ability to present scientific data internally/externally

 

 

Why Join Us

 

X-Chem offers competitive compensation and benefits programs designed to meet the diverse needs of our global colleagues. Our Pay for Performance philosophy and practices reward colleagues based on the contributions they make to our business.

Our competitive benefits programs support our colleagues by:

Promoting health and wellness to help colleagues maintain and improve their physical and mental wellbeing. X-Chem offerings include private health insurance, preventative health programs, and personal wellness benefits.

Offering flexible and meaningful benefits, including flexible working hours, long-term loyalty rewards, language learning opportunities, and access to experiences that encourage relaxation, recreation, and cultural enrichment.

 

How to Apply

 

If you are interested in our job advertisement, apply on our carrier page.

Related keywords

DNA-Encoded Chemical LibraryDELSmall Molecule DiscoveryOrganic SynthesisLCMSHit-to-LeadLead OptimizationMedicinal ChemistryProcess ChemistryDrug DiscoveryHigh-throughput ScreeningReaction ValidationBiotechnologyPharmaceuticals

About X-Chem, Inc.

LinkedInVisit site

Small Molecule. Exponential Discovery.

Industry
Biotechnology Research
Company size
201-500 employees
Founded
2010
Headquarters
Waltham, MA
LinkedIn followers
10,647

X-Chem is your preferred partner for innovative small molecule discovery. Synergizing DNA-encoded chemical library technology, discovery chemistry, and artificial intelligence, we provide pharmaceutical and biotech companies complete, seamless solutions for challenging, high-value therapeutic targets. With 80% success rate in identifying functional hits, ~100 programs licensed, 4 clinical candidates since 2021, and our technologies proven in ~30 challenging target classes, we are committed to helping create molecules that will improve human health. We work closely with our partners at any stage of early drug discovery, including screen-to-hit, hit-to-lead, lead optimization, and/or candidate identification to maximize project success. Our extensive expertise guarantees quality results, bringing our partners’ novel therapy closer to the clinic. Our clients benefit from flexible access to our innovations, including integrated project support, screening and follow-up, or access to our ArtemisAI software platform.

Offices: 100 Beaver St., Waltham, MA 02453, US · 4800 Rue Lévy, Montreal, Quebec H4R 2P1, CA · Graphisoft Park (Building D) 1031, Budapest, Záhony utca 7 1031, HU · 1 Ariel Way, London, England W12 7SL, GB

Health CareBiotechnology
View all jobs at X-Chem, Inc.

About X-Chem, Inc.

LinkedInVisit site

Small Molecule. Exponential Discovery.

Industry
Biotechnology Research
Company size
201-500 employees
Founded
2010
Headquarters
Waltham, MA
LinkedIn followers
10,647

X-Chem is your preferred partner for innovative small molecule discovery. Synergizing DNA-encoded chemical library technology, discovery chemistry, and artificial intelligence, we provide pharmaceutical and biotech companies complete, seamless solutions for challenging, high-value therapeutic targets. With 80% success rate in identifying functional hits, ~100 programs licensed, 4 clinical candidates since 2021, and our technologies proven in ~30 challenging target classes, we are committed to helping create molecules that will improve human health. We work closely with our partners at any stage of early drug discovery, including screen-to-hit, hit-to-lead, lead optimization, and/or candidate identification to maximize project success. Our extensive expertise guarantees quality results, bringing our partners’ novel therapy closer to the clinic. Our clients benefit from flexible access to our innovations, including integrated project support, screening and follow-up, or access to our ArtemisAI software platform.

Offices: 100 Beaver St., Waltham, MA 02453, US · 4800 Rue Lévy, Montreal, Quebec H4R 2P1, CA · Graphisoft Park (Building D) 1031, Budapest, Záhony utca 7 1031, HU · 1 Ariel Way, London, England W12 7SL, GB

Health CareBiotechnology
View all jobs at X-Chem, Inc.

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