Director, Alliance Management
About this role
Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Associate Director/Director, Alliance Management is responsible for leading and optimizing strategic collaborations with pharmaceutical, biotechnology, academic, and technology partners. This role serves as the primary relationship manager for one or more high-value alliances, ensuring alignment of strategic objectives, effective governance, operational excellence, and successful execution of contractual obligations.
The successful candidate will work cross-functionally with Research, Clinical Development, Regulatory Affairs, Commercial, Legal, Finance, Manufacturing, and Executive Leadership to maximize the value of partnerships while proactively identifying and mitigating risks.
The ideal candidate is a strategic, collaborative leader who excels at building trusted partnerships and navigating complex cross-functional environments and coordinating across internal and external stakeholders. They combine scientific understanding with business acumen, possess exceptional communication and influence skills, and have a demonstrated ability to maximize the value of strategic biotechnology alliances while ensuring operational excellence and long-term partner success. They drive alignment between internal priorities and partner expectations and ensure that Tango has a reputation as a good partner.
Your Role:
Strategic Alliance Leadership
- Serve as the primary alliance manager for strategic research, development, licensing, and commercialization partnerships
- Develop and execute alliance management strategies aligned with corporate objectives
- Foster trusted relationships with partner organizations at operational and executive levels
- Ensure partnerships achieve agreed milestones, deliverables, and value creation objectives
Governance & Collaboration
- Establish and manage joint governance committees, including Joint Steering Committees (JSCs), Joint Development Committees (JDCs), and Joint Project Teams
- Plan governance meetings, prepare agendas, facilitate discussions, document decisions, and track action items
- Ensure effective communication and decision-making across partner organizations
- Coordinate escalation and resolution of strategic or operational issues
Contract & Financial Management
- Monitor compliance with collaboration agreements, licensing terms, and governance obligations
- Coordinate milestone tracking and financial obligations, including payments, royalties, and budget planning
- Partner with Legal on amendments, contract interpretation, and issue resolution
- Support alliance-related forecasting and financial reporting
- Monitor execution against project timelines and contractual commitments
Issue Resolution & Risk Management
- Identify emerging partnership risks and develop mitigation strategies
- Facilitate conflict resolution while maintaining productive long-term relationships
- Escalate significant issues to executive leadership as appropriate
Performance Monitoring
- Develop and monitor alliance performance metrics and KPIs
- Conduct periodic health assessments of strategic partnerships
- Recommend continuous improvement initiatives to enhance collaboration effectiveness
- Excellent project management capabilities to manage respective alliances
Executive Communication
- Prepare executive-level presentations, dashboards, and alliance status reports
- Present partnership updates to senior leadership and governance committees
- Support due diligence and integration planning for new collaborations
What You Bring:
- Advanced degree (PhD or MBA) with a minimum of 6 or 8 years of relevant alliance management experience, respectively, or a Bachelor’s degree with a minimum of 10 years of relevant alliance management experience
- Demonstrated alliance management experience within the biotechnology or pharmaceutical industry
- Global alliance management experience preferred
- Experience managing complex research, clinical development, licensing, or commercialization collaborations
- Knowledge of drug development from discovery through commercialization preferred
- Preferred background in oncology or rare diseases
- Experience with co-development, co-commercialization, or platform technology collaborations
- Familiarity with alliance management best practices and tools
Flex Designation:
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Company at a glance
Tango Therapeutics is a clinical-stage biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Tango was launched in 2017 with a $55 million Series A investment from Third Rock Ventures. The company has established a robust product engine that leverages advances in DNA sequencing and CRISPR-based target discovery to generate breakthrough medicines that have the potential to provide deeper, more sustained benefit than today’s targeted therapies, and extend the benefit of available immuno-oncology agents.
Tango Therapeutics is focused on three areas of drug development, each in well-defined patient populations currently lacking effective treatment options, and each with hallmarks of cancer that have not been targeted yet. These include: loss of tumor suppressor gene function; multiple oncogenic drivers; and immune evasion.
What fuels each of Tango’s programs is an increasingly sophisticated ability to utilize synthetic lethality - the interaction between two genes that causes cell death when both are inactivated. In cancer cells, one of these genes is inactivated by mutation; the other will be inactivated by a drug. This approach leaves normal cells largely unaffected, with the potential to greatly enhance anti-tumor efficacy and reduce associated toxicity.
Tango’s success will be driven by its depth of understanding of the genetic subtypes of cancer, and corresponding insights into novel drug targets and combinations uniquely relevant to each subtype. By shaping discovery efforts in this way, Tango has the potential to reach the clinic quickly, and with a clear plan for identifying the patients most likely to benefit from each new treatment, an approach that could increase both speed and probability of success in translating novel target discoveries into transformational new medicines for patients.
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