Principal Mechanical Engineer
About this role
Company Overview
Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights.
We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications.
At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality.
We are seeking a Principal Mechanical Engineer to serve as instrument lead for our point-of-care molecular diagnostic platform, owning the mechanical and electromechanical architecture from concept through product launch.
This is a hands-on senior individual contributor role. You will personally drive the design of both the instrument and its custom consumable, set the technical direction for outsourced design partners and contract development and manufacturing organizations (CDMOs), and establish the engineering practices that a growing internal hardware team will build on. The role operates with a high degree of independence, with the opportunity to scope and grow internal engineering capability as the platform matures. This is an on-site position based in San Diego, California.
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Translate assay, biological, and user requirements into robust mechanical and electromechanical hardware architectures; define product requirements and subsystem specifications for fluidics-based instrumentation.
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Serve as the technical lead for instrument development from concept through design transfer, product launch, and sustaining support.
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Lead and support the design and integration of fluidic components, motion and actuation systems, thermal modules, optical interfaces, and the mechatronic and electrical systems that tie them together.
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Lead the design of custom consumables and disposable cartridges, including fluidic routing, valving, sealing, and the registration and alignment mechanisms that define the instrument-to-consumable interface.
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Develop precise thermal modules for amplification and thermal cycling, heating and cooling management, and automated motion systems.
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Perform hands-on design and build of breadboard systems, functional prototypes, and reliability test stations.
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Apply analysis methods such as FEA, CFD, GD&T, and tolerance stack-up analysis to guide and de-risk designs.
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Own and manage outsourced design partnerships, CDMOs, and key technology vendors, including scope definition, design reviews, milestone acceptance, and technical escalation.
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Drive DFM and DFA across injection molding, machining, joining, and automated assembly processes, and support pilot builds and transfer to manufacturing.
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Define and support design verification testing at the system and subsystem level, including reliability, durability, and environmental testing.
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Author and maintain design inputs and outputs, risk analyses, and design history file content as the platform advances from research use toward a regulated in vitro diagnostic product.
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Drive alignment with molecular biology, assay development, software, and manufacturing counterparts; mentor engineers and help define the internal hardware function as the team grows.
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Proven track record of designing reliable electro-mechanical, fluidic, optical and thermal systems throughout the product development life cycle, from concept to product launch to sustaining support
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Experience with designs for fluidically driven systems, preferably for microfluidic applications in the life science, molecular diagnostic, or point-of-care fields
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Demonstrated experience designing or supporting custom consumables and their associated registration and alignment mechanisms
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Working fluency across fluidic, optical, mechatronic, and electrical systems sufficient to own system-level architecture and integration decisions
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Proven track record with design for manufacturability, with a working understanding of a variety of manufacturing processes including injection molding, machining, and automated assembly
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Fluency in SolidWorks CAD, with strong command of GD&T and tolerance stack-up analysis
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Strong collaboration skills and demonstrated experience directing vendors, outsource design partners, and CDMOs, with accountability for their technical deliverables
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Comfort operating as a hands-on individual contributor in an early-stage environment, with the judgment to determine what to build internally versus outsource
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Excellent written and oral communication skills
Preferred Qualifications
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Experience applying FEA and CFD tools to thermal, fluid, and structural analysis
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Experience developing medical devices or in vitro diagnostics under FDA design controls and ISO 13485, and/or familiarity with cGMP manufacturing environments
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Experience with point-of-care or near-patient instrument constraints, including size, cost, usability, and robustness outside of a laboratory setting
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Experience with nucleic acid amplification instrumentation (PCR or isothermal) or automated sample preparation
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Experience with manufacturing systems and workflows, pilot production, and design transfer
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Experience mentoring engineers or standing up an internal engineering function
Sarmal offers a competitive and comprehensive benefits package, including:
- Medical, dental, and vision coverage
- Company-paid life insurance
- 401(k) retirement plan
- Generous paid time off
- Access to additional voluntary benefits, employee perks, and discount programs
- We are committed to supporting the well-being of our employees and providing a strong foundation for both professional and personal success.
California Pay Transparency Statement.
The anticipated salary range for this position is $165,000 – $200,000, depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations.
EEO Statement
Sarmal is an equal opportunity employer committed to building a diverse and inclusive workplace. We do not discriminate based on race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran status, or any other characteristic protected by applicable federal, state, or local laws.
Reasonable Accommodation Statement
Sarmal is an equal opportunity employer that values diversity and inclusion. We welcome applicants of all backgrounds and consider all qualified candidates in accordance with applicable laws.
Why Join Sarmal
- Work on cutting-edge genomics and molecular detection technologies
- Collaborate with a deeply technical, cross-functional team
- Contribute to foundational platform development at an early stage
- Have visibility into and impact on core technical and strategic decisions
- Help shape the infrastructure, culture, and future direction of the company
Closing Statement
Join us in advancing the next generation of genomic technologies and shaping the future of precision health.
Company at a glance
Sarmal is a San Diego-based entrepreneurial research and development team developing breakthrough technologies in advanced nucleic acid sequencing and nucleic acid-based detection.
We bring together interdisciplinary expertise across biology, chemistry, engineering, and software to build these transformative genomic technologies.
If you're interesting in joining our mission, check out our job postings or learn more at website.
Top Benefits
- Medical coverage
- Dental coverage
- Vision coverage
- Company-paid life insurance
- 401(k) retirement plan
- Generous paid time off
- Employee perks
- Discount programs
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