Senior Scientist, Macrophage-stromal biology
About this role
Your mission
We are seeking an accomplished Senior scientist of macrophage biology to provide scientific leadership in macrophage biology and immune-stromal interactions, driving target identification, validation and translational strategy across our fibrosis and oncology discovery portfolio.We are looking for an expert in macrophage biology who will use their experience to establish macrophage-based target screening assays combined with our novel extracellular matrix-based cell models, utilising cellular, immunological, biochemical, molecular biology and functional genomic approaches. You will also provide scientific mentorship and technical guidance to scientists across discovery programmes, champion innovative approaches and emerging technologies in macrophage and immune-stromal biology, and represent macrophage biology expertise within cross-functional project teams.
Key Responsibilities
- Establish a suite of macrophage functionality assays to target discovery and drug discovery flowcharts, including activation, cytokine secretion, phagocytosis and efferocytosis assays.
- Optimise macrophage target screening-based systems utilising annotated lmw libraries and functional genomic approaches such as siRNA and CrispR library-based approaches.
- Lead a small team of immunologists/cell biologists involved in execution of projects across both the internal and external biopartnerships.
- Lead the build novel macrophage drug target nomination packages and present case to the leadership for portfolio entry.
- Analyse, interpret, report and present results.
Your profile
Key Experience- Demonstrable expertise in macrophage biology, in particular phagocytosis pathways.
- Demonstrable experience in target nomination and validation in a biotech or pharmaceutical based setting.
- Expertise in the use of multi-colour flow cytometry and IF techniques.
- Hands-on experience of key immunological and molecular biology techniques including MSD, RNA/DNA. extraction, qRT-PCR, western blotting, siRNA knockdown.
- Have team and direct people leadership experience.
- Familiarity with molecular pharmacology and oncology drug development would be an advantage.
- Prior working experience in the biotech/pharma industry performing laboratory research would be a further plus.
Qualifications and Competencies
- PhD in Biomedical sciences, Immunology, Biochemistry, Biotechnology or related discipline plus 4 years’ experience in drug screening setting or MSc plus 8 years practical experience with a focus on immuno-oncology or fibrosis.
- Ability to plan, execute and critically assess experiments independently.
- Excellent time-management skills and ability to work to set deadlines.
- You will be expected to work well within a team, have strong written and verbal communication skills, as well as IT skills.
- You will troubleshoot effectively, work methodically, stay well organised, pay close attention to detail, and maintain accurate records.
Why us?
- Be part of a pioneering biotech transforming drug discovery through ECM biology
- Work in a collaborative, fast-paced environment with opportunities to shape the future of targeted therapeutics
- We offer a competitive package including private medical insurance, pension, bonus, employee perks and more!
About us
Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.
Company at a glance
To create a healthier future for patients with life-threatening diseases, we are using our pioneering human extracellular matrix (ECM)-based discovery platform to develop a portfolio of programmes in fibrosis and solid tumours.
Using human in vitro models that better recreate the natural cell microenvironment is transforming our ability to identify new targets, determine mechanisms of action, and increase the success rate of therapeutic candidates.
We have pioneered the world’s first human extracellular matrix-based discovery platform to aid in the discovery of targets and biomarkers as well as drug profiling. Using our technology, we have a unique ability to study tissue- and disease-specific human ECM scaffolds, and to model diseases to study mechanisms of action. Our improved understanding of the role of the ECM in human enables the identification of more relevant drug targets and biomarkers. For drug discovery, we incorporate human ECM into our in vitro models, thereby recreating the natural cell microenvironment so that drug candidates can be tested in the context they will ultimately be used in. With the potential to predict the efficacy of candidates more accurately at an earlier stage, the platform can reduce late-stage clinical failures and accelerate discovery.
Top Benefits
- Private medical insurance
- Pension
- Bonus
- Employee perks
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