Research Associate I, CFPS Production
About this role
Research Associate I, CFPS Production
Department: Lab Science
Employment Type: Full Time
Location: San Mateo, CA
Description
Key Responsibilities
- Manufacture and validate CFPS reagents used in BigHat’s high-throughput antibody screening platform including making buffers, media for biomass production and performing QC experiments on reagents.
- Maintain CFPS reagent manufacturing equipment including incubators, centrifuges, and homogenizers.
- Coordinate with lab ops team to request/order supplies for CFPS reagent manufacturing to ensure reliable stock for platform.
- Design and run experiments for development of next generation CFPS extract to optimize yield and purity of next generation antibodies on our platform.
- Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges.
- Present experimental plans and results during regular meetings with manager and science teams.
Skills Knowledge and Expertise
- B.S. degree in Biochemistry, Molecular Biology, or related field with 1-2 years of industry experience.
- Experience working with recombinant protein expression from bacterial cultures. Experience with CFPS is highly desired but not required.
- Experience with molecular cloning techniques including primer design, PCR, mutagenesis, Golden Gate Assembly.
- Preferred: Experience and knowledge of protein purification methods including affinity chromatography and SEC.
- Excellent communication skills; organized and works well in small groups.
- Experience with quantitative and/or statistical analysis software is a plus (e.g. Excel, GraphPad Prism, Python, R, etc.)
- Experience with automation and high-throughput tools and robotic instrumentation is a plus.
Total Rewards
What BigHat Offers:
- Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
- Dental, and vision coverage through Guardian
- Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
- 401(k) with company match
- DTO, two weeks of company-wide shutdown, and 12 company holidays
- Paid parental leave
Company at a glance
BigHat's mission is to improve human health by making it far easier to design advanced, next-generation antibody therapeutics. The company works to accelerate the development of these therapies and positions itself at the forefront of antibody design. BigHat is backed by a notable group of investors, including Section 32, Andreessen Horowitz, 8VC, Amgen Ventures, Bristol Myers Squibb, Quadrille, Grids Capital, AME Cloud Ventures, Innovation Endeavors and Gaingels. This strong investor lineup provides credibility and support as BigHat pursues its mission in the biotech market.
Top Benefits
- Health Insurance
- Dental Insurance
- Vision Insurance
- Well-being Benefits
- 401(k) With Company Match
- Discretionary Time Off
- Company-wide Shutdown
- Company Holidays
- Paid Parental Leave
- Bonus
- Stock Options
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