Scientist to Principal Scientist, in-vitro Biology

Job Title: S/SS/PS, in vitro Biology

Reports To: SD of Biology

Location: Shanghai, China

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

This role is pivotal in driving the research pipeline and advancing drug discovery initiatives. The successful candidate will provide expertise in in vitro biology and assay development, establish core in vitro pharmacology capabilities, and oversee the design and execution of in vivo studies, including monitoring work conducted both internally and through CRO partners.

Job Responsibilities:

• Study disease and target biology to evaluate new targets. Propose new projects.
• Establish in vitro and in vivo biology related competencies.
• Lead biology and drive discovery project to progress and achieve milestones
• Design and execute biology studies to support target validation and drug candidate discovery. Ensure that experiments are performed to a consistently high standard
• Manage out-sourced studies with CROs and/or academic collaborators
• Responsible for data review, analysis and interpretation to enable program go/no-go decisions
• Work with research teams to manage multiple projects
• Support team members
• Interpret and present scientific findings at internal and external research meetings
• Collaborate and communicate across a diverse research team to progress scientific goals

Qualifications:

• PhD in Biology or related field with at least 2 years of post-doctoral experience. Industrial experience is preferred
• Hands on experience of in vivo pharmacology work is a plus.
• Deep understanding of GPCR and receptor pharmacology and/or enzymology.
• Solid understanding of disease biology of metabolic disease is a plus.
• Experience in discovering and validating drug targets and in progressing molecules into lead optimization. Experience in driving projects towards IND is preferred
• Excellent verbal and written communication skills with an ability to organize and communicate complex data sets in a clear and concise manner
• Demonstrated ability to work effectively in cross-functional team.
• Prior experience working at fast-paced biotech is preferred

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, ongoing performance-based equity and various benefits offerings.

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We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.

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