Principal Scientist to Associate Director, Del Hit ID Lead

Job Title:  SS or PS or AD, DEL Hit ID Lead

Reports To: Executive Director, Affinity Selections

Location: Shanghai, China

About Us:

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

We are seeking a highly skilled and communication-strong DEL Hit ID Lead to drive the execution, coordination, and scientific integration of DNA-Encoded Library (DEL) campaigns across multiple early discovery programs. This individual will serve as a key connector between DEL science, reagent generation, discovery units consisting of chemistry/pharmacology/biology/CADD/Cheminformatics, and CRO partners.

This role is ideal for a scientist with a deep understanding of DEL or related small molecules Hit ID methods (HTS, phage display, or mRNA display), paired with exceptional cross-functional communication, troubleshooting capability, and program leadership.  It is a high-impact scientific leadership position that ensures clarity, alignment, and timely delivery of DEL Hit ID outcomes.

Job Responsibilities:

DEL Campaign Leadership & Execution

• Lead day-to-day scientific and operational management of DEL campaigns across discovery programs.
• Translate high-level DEL and Hit ID strategies into actionable plans, clear deliverables, timelines, and decision points.
• Partner with DEL Director and scientist to ensure coordinated campaign execution and timely resolution of scientific or operational challenges

Scientific Integration & Troubleshooting

• Partner with DEL Director to refine campaign design and execution choices.
• Guide scientific interpretation of DEL screening data and hit triage decisions.
• Troubleshoot technical or data-related issues arising from DEL experiments or CRO workflows.
• Collaborate with in vitro assays/CADD/Structure Biology/Medicinal chemistry to support hit triage and chemotype evaluation

Cross-Functional Alignment & Communication

• Serve as the primary liaison to different functions across cycles of DEL campaign from pre-selection to hit confirmation.
• Provide clear, concise updates to project teams and leadership.
• Ensure DEL requirements (reagents, assays, timelines) are understood and synchronized across stakeholders.

CRO & External Partner Management

• Act as the operational and scientific lead for DEL CRO relationships and consultants.
• Ensure SOWs reflect correct scientific intent and feasible execution plans.
• Track scientific and operational deliverables from external partners.
• Evaluate and refine scopes of work to optimize efficiency and scientific outcomes.

Strategic Enablement & Team Development

• Identify process improvements, workflow bottlenecks, and opportunities to enhance DEL campaign efficiency and robustness.
• Contribute to broader DEL and Hit ID strategic planning, platform improvement, and capability building.

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Qualifications:

Required

• Ph.D. or M.S./B.S with industry experience in DEL, HTS, or phage display, chemical biology, computation chemistry, biophysics, assay biology, or Chemistry
• 5–10+ years of experience in small-molecule Hit Identification, preferably including DEL
• Strong foundational understanding of DEL workflows and interpretation of screening outcomes
• Proven ability to lead cross-functional scientific programs without direct reports
• Excellent written and verbal communication skills; clarity, structure, and influence
• Demonstrated success managing CROs or external scientific partners
• Strong troubleshooting mindset, with ability to quickly identify root causes and propose solutions
• Ability to balance strategic thinking with operational execution
• Fluent in English and Mandarin

Preferred

• Experience with DEL screening campaigns, data analysis interpretation, or library design
• Familiarity with computational hit triage or cheminformatics (direct or through partnership)
• Understanding of reagent requirements for Hit ID and early discovery workflows
• Experience mentoring or guiding team members in scientific communication or project alignment

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, ongoing performance-based equity and various benefits offerings.

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