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Foresite Labs (Stealth Co)

Sr Staff Engineer, R&D, Mechanical Engineer

full-time•San Diego

Summary

Location

San Diego

Type

full-time

Experience

10+ years

Company links

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About this role

Sr Staff Engineer, R&D, Mechanical Engineer

In this role as a Sr Staff Mechanical Engineer, you’ll drive the design of an innovative automation system for precision handling and processing of custom parts, with modules for transfer & positioning, thermal control, and controlled fluid storage and dispense. The role will exercise expertise in precision machine design, electro-mechanical control systems, and metrology development. You will be a key member of the core engineering team responsible for defining and delivering our flagship platform.

The responsibilities of this role include:

· System Architecture:

· Define requirements, specifications, tolerance stacks, and error budgets for mechanical subsystems.

· Conduct trade studies to optimize architecture for performance, manufacturability, cost, and reliability.

· Own the mechanical system architecture for part processing and precision fluid management modules.

· Design & Development

· Design, develop, and validate complex, high-performance electromechanical assemblies for:

· Part transfer and precision positioning

· Thermal control and temperature uniformity

· Fluid storage and precision dispense

· Controlled environmental systems (temperature, humidity, air purity)

· Develop metrology solutions for system monitoring, including:

· Machine vision for position and alignment measurement

· Optical or imaging-based fluid contamination detection

· Dynamic spatial temperature measurement and calibration

· Select and integrate key components such as motors, bearings, encoders, drives, pneumatics, pumps, valves, sensors, seals, heaters, and thermoelectrics.

· Cross-Functional Integration

· Collaborate closely with systems, electrical, and software engineers to align mechanical and control architectures.

· Partner with assay scientists to ensure mechanical designs meet biological and chemical requirements.

· Work with operations, manufacturing, and supply chain to ensure scalability, cost-efficiency, and high-quality builds.

· Prototyping, Testing & Validation

· Lead prototype builds and iterative design improvements based on empirical test results.

· Define and execute mechanical and system-level verification and validation plans.

· Analyze performance data and reliability metrics to drive continuous improvement.

Minimum qualifications

· B.S. or M.S. in Mechanical Engineering or related field.

· 10–15+ years of experience designing precision electromechanical or fluidic systems for production instruments or automation platforms.

· Proven ownership of complex systems from concept through product launch.

· Expert in 3D CAD (SolidWorks) with strong proficiency in GD&T and detailed mechanical drawings.

· Deep expertise in machine design and precision motion systems.

· Strong analytical and modeling skills — mechanical, thermal, and system-level.

Preferred qualifications

· Experience in bioinstrumentation, analytical devices, or medical instruments

· Working knowledge of embedded controls, sensors, and mechatronic integration.

· Experience mentoring other engineers and influencing design culture.

What you'll do

  • The Sr Staff Mechanical Engineer will drive the design of an innovative automation system for precision handling and processing of custom parts. Responsibilities include defining system architecture, designing and developing electromechanical assemblies, and leading prototyping and testing efforts.

About Foresite Labs (Stealth Co)

Foresite Labs creates companies at the intersection of AI/machine learning and science. We believe AI, generative AI, and data science—when applied with scientific rigor—can accelerate discovery and drive innovations that benefit humanity. We provide the foundation for bold ideas to take shape and accelerate, shaping a better future for all. We offer competitive salaries, excellent benefits, and a flexible work environment where employees learn from top thinkers across multiple disciplines. With headquarters in San Francisco and Boston, we’re building a culture where scientific rigor meets entrepreneurial ambition. Foresite Labs Values Truth over progression: We follow the science, pursuing ideas that are grounded in data and abandoning them when not supported by the evidence. Take good risks: Our culture values informed risk-taking: good decisions are celebrated even when they result in bad outcomes. Everyone feels safe to contribute ideas and to learn from failure. Single accountable person: The project team lead is accountable for all decisions and for maintaining transparency and information flow within the team; we trust the project teams. The Review Committee unlocks capital and sets directions. Simplicity and Focus: “Companies die from indigestion, not starvation” (Bill Hewlett) We will focus on a few ideas aggressively and minimize all other distractions. Everyone will have a few key goals that have measurable outcomes. Respect and Community: Our employees are our greatest asset; everyone invests in creating an environment of collaboration and respect. We support their careers and career development whether they stay, go to a Labs company, or end up somewhere else.

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Frequently Asked Questions

What does a Sr Staff Engineer, R&D, Mechanical Engineer do at Foresite Labs (Stealth Co)?

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As a Sr Staff Engineer, R&D, Mechanical Engineer at Foresite Labs (Stealth Co), you will: the Sr Staff Mechanical Engineer will drive the design of an innovative automation system for precision handling and processing of custom parts. Responsibilities include defining system architecture, designing and developing electromechanical assemblies, and leading prototyping and testing efforts..

Is the Sr Staff Engineer, R&D, Mechanical Engineer position at Foresite Labs (Stealth Co) remote?

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The Sr Staff Engineer, R&D, Mechanical Engineer position at Foresite Labs (Stealth Co) is based in San Diego, California, United States. Contact the company through Clera for specific work arrangement details.

How do I apply for the Sr Staff Engineer, R&D, Mechanical Engineer position at Foresite Labs (Stealth Co)?

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You can apply for the Sr Staff Engineer, R&D, Mechanical Engineer position at Foresite Labs (Stealth Co) directly through Clera. Click the "Apply Now" button above to start your application. Clera's AI-powered platform will help match your profile with this opportunity and guide you through the application process.
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