FL
Senior Engineer – Signal Processing
full-time•San Diego•$260k - $270k
About this role
Principal Engineer – Signal Processing
Location: San Diego, CA
Job Type: Full-Time
$260,000-$270,000
About Us
We are a venture-backed, stealth-stage biotechnology company based in San Diego, focused on developing novel technologies that will redefine how disease is detected, characterized, and managed with a novel approach to clinical genomics. Our mission is to fundamentally transform healthcare through a convergence of innovation across multiple scientific disciplines.
Founded by industry veterans with decades of experience in life sciences tools and diagnostics, our leadership team brings a proven track record of translating scientific insight into successful commercial products. Our investors include some of the most respected names in healthcare and deep tech.
Position Overview
We are seeking a Principal Engineer – Signal Processing to lead our efforts in creating a high-throughput, optimized bioinformatic signal pipeline. You will use your background in image processing, signal processing, discrete data transmission and communication theory to create a pipeline that extracts the maximum possible amount of information from our dense and noisy biological assays. You will design and deploy a data pipeline that uses adaptive filtering, physics-based modeling, decision-based feedback, and other techniques borrowed from telecommunication theory to process the high-throughput stream of data generated by our instruments. Although the underlying physical systems may be new to you, the math will not and you will adapt familiar concepts such as signal-to-noise ratio and maximum-likelihood detection to develop novel algorithms addressing unique challenges. The ideal candidate is eager to take their experience in signal processing and apply it to decoding signals from complex biological systems that will advance our mission to radically improve healthcare.
Key Responsibilities
Architect a data processing pipeline that transforms biological signals into discrete data sources for downstream processing.
Develop novel algorithms and implement proven algorithms in novel ways to optimize throughput and quality of biological detection systems.
Define metrics and diagnostics for the hardware and chemistry teams that allow them to optimize workflow and instrumentation to achieve the highest possible data quality.
Define metrics and diagnostics for the bioinformatics team that allow them to optimize performance of downstream assays and applications.
Create a modeling and analysis framework to predict future performance and identify key parameters limiting potential data quality. Work with chemistry and hardware teams to prioritize experiments that will guide the system to its theoretical limits.
Contribute to the design of future hardware and assays that reach beyond current capabilities to deliver truly groundbreaking results.
Qualifications
Education
MS or PhD in Electrical Engineering, Computer Science, Physics, Bioinformatics, or related field.
Minimum Qualifications
MS and 13+ years or PhD and 10+ years of experience in digital or analog signal processing, image analysis, communications, physical layer algorithm development or comparable field.
Deep understanding of signal processing, digital communication, and optimal system design.
Proficiency in Python, MATLAB, C++ or similar language and hig performance computing frameworks.
Preferred Qualifications
Familiarity with machine learning techniques for image processing, channel optimization, or related areas.
Experience with GPU-accelerated computation (CUDA, RAPIDS, etc.)
Experience in cross-functional collaboration with engineering, chemistry and biochemistry teams.
Record of innovation through publications, patents or open-source contributions.
Why Join Us
Influence the foundational technologies and strategies of a company poised to shape the future of clinical genomics and healthcare.
Work in a dynamic, collaborative environment where innovation and scientific rigor are deeply valued.
Join a seasoned and multidisciplinary team tackling high-impact problems at the intersection of science and engineering.
Competitive compensation and equity package, comprehensive benefits, and flexibility to support work-life integration.
We are an equal opportunity employer. We thrive on diversity and collaboration.
What you'll do
- The engineer will architect a data processing pipeline to transform biological signals into discrete data sources and develop novel algorithms to optimize the throughput and quality of biological detection systems. Key tasks include defining metrics for hardware/chemistry and bioinformatics teams, and creating modeling frameworks to predict performance and guide system optimization.
About Foresite Labs (Stealth Co)
Foresite Labs creates companies at the intersection of AI/machine learning and science. We believe AI, generative AI, and data science—when applied with scientific rigor—can accelerate discovery and drive innovations that benefit humanity.
We provide the foundation for bold ideas to take shape and accelerate, shaping a better future for all. We offer competitive salaries, excellent benefits, and a flexible work environment where employees learn from top thinkers across multiple disciplines. With headquarters in San Francisco and Boston, we’re building a culture where scientific rigor meets entrepreneurial ambition.
Foresite Labs Values
Truth over progression: We follow the science, pursuing ideas that are grounded in data and abandoning them when not supported by the evidence.
Take good risks: Our culture values informed risk-taking: good decisions are celebrated even when they result in bad outcomes. Everyone feels safe to contribute ideas and to learn from failure.
Single accountable person: The project team lead is accountable for all decisions and for maintaining transparency and information flow within the team; we trust the project teams. The Review Committee unlocks capital and sets directions.
Simplicity and Focus: “Companies die from indigestion, not starvation” (Bill Hewlett) We will focus on a few ideas aggressively and minimize all other distractions. Everyone will have a few key goals that have measurable outcomes.
Respect and Community: Our employees are our greatest asset; everyone invests in creating an environment of collaboration and respect. We support their careers and career development whether they stay, go to a Labs company, or end up somewhere else.
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Frequently Asked Questions
What does Foresite Labs (Stealth Co) pay for a Senior Engineer – Signal Processing?
Foresite Labs (Stealth Co) offers a competitive compensation package for the Senior Engineer – Signal Processing role. The salary range is USD 260k - 270k per year. Apply through Clera to learn more about the full compensation details.
What does a Senior Engineer – Signal Processing do at Foresite Labs (Stealth Co)?
As a Senior Engineer – Signal Processing at Foresite Labs (Stealth Co), you will: the engineer will architect a data processing pipeline to transform biological signals into discrete data sources and develop novel algorithms to optimize the throughput and quality of biological detection systems. Key tasks include defining metrics for hardware/chemistry and bioinformatics teams, and creating modeling frameworks to predict performance and guide system optimization..
Is the Senior Engineer – Signal Processing position at Foresite Labs (Stealth Co) remote?
The Senior Engineer – Signal Processing position at Foresite Labs (Stealth Co) is based in San Diego, California, United States. Contact the company through Clera for specific work arrangement details.
How do I apply for the Senior Engineer – Signal Processing position at Foresite Labs (Stealth Co)?
You can apply for the Senior Engineer – Signal Processing position at Foresite Labs (Stealth Co) directly through Clera. Click the "Apply Now" button above to start your application. Clera's AI-powered platform will help match your profile with this opportunity and guide you through the application process.