About this role
Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
A postdoctoral position is open in the laboratory of Yingfeng Deng in the Department of Diabetes and Cancer Metabolism at the City of Hope Beckman Research Institute. The Deng laboratory studies the homeostasis of uridine and its role in metabolism, which provides a new angle for understanding the pathophysiology of obesity, diabetes and cancer.
Work in the lab utilizes both genetically engineered mouse models and in vitro systems. A combination of state-of-the-art surgical, genetic, cellular, biochemical, imaging, and metabolic flux approaches is currently used in the lab. Following up with the new paradigm revealed about uridine metabolism by Drs. Deng and Scherer (Science, 2017), the Deng lab is currently focusing on three areas: 1) the role of uridine in the progression of obesity and diabetes. 2) the physiology of uridine in bile and nutrient absorption. 3) the regulation of uridine homeostasis by ER stress and its relevance to breast cancer.
We seek an independent and highly motivated candidate interested in studying the molecular, cellular, and metabolic mechanisms leading to obesity, diabetes, and cancer. Expertise in using mouse models to study metabolic diseases is preferred.
For a complete list of Publications please visit here: https://www.ncbi.nlm.nih.gov/myncbi/1J54E41I5YVku/bibliography/public/
Your qualifications should include:
· Ph.D. and/or M.D. degree in life or biomedical sciences or a related discipline is required.
· Experience in basic molecular biology skills.
· Experience in animal models and lipid metabolism.
· Experience in metabolomics and liver physiology.
· To Apply, please attach a cover letter describing your past training and research interests, a detailed CV and contact information of three referees
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer.
To learn more about our Comprehensive Benefits, please CLICK HERE.
Other facts
About City of Hope
City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. City of Hope’s affiliated group of organizations includes Translational Genomics Research Institute and AccessHope™.
What you'll do
- The postdoctoral fellow will study the homeostasis of uridine and its role in metabolism, focusing on obesity, diabetes, and cancer. The work will involve utilizing genetically engineered mouse models and various state-of-the-art research techniques.
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