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Scientist, Preclinical Operations
full-time•Newark•$131k - $160k
About this role
Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA® (tenapanor) and XPHOZAH® (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL® (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada.
Position Summary:
We are seeking a Scientist, Preclinical Operations to join our experienced drug discovery and development team and help advance our gastrointestinal (GI) and cardiorenal research programs. The successful candidate will contribute to the development of GI/cardiorenal translational and biomarker strategies and provide scientific support across multiple drug programs.
A key component of this role will be coordinating and monitoring work conducted by contract research organizations (CROs), with a focus on evaluating drug targets and mechanisms involved in GI and cardiorenal pathophysiology in support of the company’s discovery and development efforts.
Responsibilities:
- Identify, establish and manage collaborations with CROs and academic institutions and key opinion leaders in relevant disease areas for research projects
- Assist with the development and execution, through CROs, relevant in vivo models critical for evaluating compound activity, mechanism of action, and generation of key data sets that drive drug programs
- Review, analyze, and summarize data; prepare high-quality presentations for internal discussions
- Support drug discovery efforts, including scientific due diligence and preclinical de-risking of GI/cardiorenal opportunities
- Collaborate with drug development teams to generate IND-enabling data
- Track project resources and invoices
- Author scientific reports and supporting documentation for IND submissions
Qualifications:
- Ph.D. in biology, pharmacology, or related discipline with 2 - 5 years of related experience or equivalent experience
- Experience outsourcing work to CROs located in the US or abroad
- Prior experience in the pharmaceutical or biotechnology industry preferred
- Experience or knowledge in gut physiology, including the role of intestinal receptors and transporters, is desirable
- Strong commitment to high-quality research and timely, organized execution of research plans
- Excellent written and verbal communication skills, with the ability to collaborate effectively in a dynamic, cross-functional team environment
The anticipated annualized base pay range for this full-time position is $131,000 - $160,000. Ardelyx utilizes industry data to ensure that our compensation is competitive and aligned with our industry peers. Actual base pay will be determined based on a variety of factors, including years of relevant experience, training, qualifications, and internal equity. The compensation package may also include an annual bonus target and equity awards, subject to eligibility and other requirements.
Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision), life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays.
Ardelyx is an equal opportunity employer.
What you'll do
- The Scientist will coordinate and monitor work conducted by CROs, focusing on evaluating drug targets and mechanisms in GI and cardiorenal pathophysiology. They will also assist in developing in vivo models and support drug discovery efforts.
About Ardelyx
Ardelyx was founded with a mission to discover, develop and commercialize innovative, first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA® (tenapanor) and XPHOZAH® (tenapanor). The company’s pipeline includes the Phase 3 development of IBSRELA for chronic idiopathic constipation (CIC) and RDX10531, a next-generation NHE3 inhibitor with potential application across multiple therapeutic areas. Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL® (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada.
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Frequently Asked Questions
What does Ardelyx pay for a Scientist, Preclinical Operations?
Ardelyx offers a competitive compensation package for the Scientist, Preclinical Operations role. The salary range is USD 131k - 160k per year. Apply through Clera to learn more about the full compensation details.
What does a Scientist, Preclinical Operations do at Ardelyx?
As a Scientist, Preclinical Operations at Ardelyx, you will: the Scientist will coordinate and monitor work conducted by CROs, focusing on evaluating drug targets and mechanisms in GI and cardiorenal pathophysiology. They will also assist in developing in vivo models and support drug discovery efforts..
Is the Scientist, Preclinical Operations position at Ardelyx remote?
The Scientist, Preclinical Operations position at Ardelyx is based in Newark, California, United States. Contact the company through Clera for specific work arrangement details.
How do I apply for the Scientist, Preclinical Operations position at Ardelyx?
You can apply for the Scientist, Preclinical Operations position at Ardelyxdirectly through Clera. Click the "Apply Now" button above to start your application. Clera's AI-powered platform will help match your profile with this opportunity and guide you through the application process.