Principal Machine Learning Engineer 

Role Name: Principal Machine Learning Engineer 

Department Name: AI & Data Science 

ABOUT AMGEN 

Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer. We discover, develop, manufacture and deliver innovative medicines to help millions of patients. Amgen helped establish the biotechnology industry more than 40 years ago and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what’s known today. 

ABOUT THE ROLE 

Role Description: 

We are seeking a seasoned Engineering Manager (Data Engineering) to lead the end-to-end management of enterprise data assets and operational data workflows. This role is critical in ensuring the availability, quality, consistency, and timeliness of data across platforms and functions, supporting analytics, reporting, compliance, and digital transformation initiatives. You will be responsible for the day-to-day data operations, manage a team of data professionals, and drive process excellence in data intake, transformation, validation, and delivery. You will work closely with cross-functional teams including data engineering, analytics, IT, governance, and business stakeholders to align operational data capabilities with enterprise needs.
 

Roles & Responsibilities:

• Lead and manage the enterprise data operations team, responsible for data ingestion, processing, validation, quality control, and publishing to various downstream systems.

• Define and implement standard operating procedures for data lifecycle management, ensuring accuracy, completeness, and integrity of critical data assets.

• Oversee and continuously improve daily operational workflows, including scheduling, monitoring, and troubleshooting data jobs across cloud and on-premise environments.

• Establish and track key data operations metrics (SLAs, throughput, latency, data quality, incident resolution) and drive continuous improvements.

• Partner with data engineering and platform teams to optimize pipelines, support new data integrations, and ensure scalability and resilience of operational data flows.

• Collaborate with data governance, compliance, and security teams to maintain regulatory compliance, data privacy, and access controls.

• Serve as the primary escalation point for data incidents and outages, ensuring rapid response and root cause analysis.

• Build strong relationships with business and analytics teams to understand data consumption patterns, prioritize operational needs, and align with business objectives.

• Drive adoption of best practices for documentation, metadata, lineage, and change management across data operations processes.

• Mentor and develop a high-performing team of data operations analysts and leads.

Functional Skills:

Must-Have Skills:

• Experience managing a team of data engineers in biotech/pharma domain companies.

• Experience in designing and maintaining data pipelines and analytics solutions that extract, transform, and load data from multiple source systems.

• Demonstrated hands-on experience with cloud platforms (AWS) and the ability to architect cost-effective and scalable data solutions.

• Experience managing data workflows in cloud environments such as AWS, Azure, or GCP.

• Strong problem-solving skills with the ability to analyze complex data flow issues and implement sustainable solutions.

• Working knowledge of SQL, Python, or scripting languages for process monitoring and automation.

• Experience collaborating with data engineering, analytics, IT operations, and business teams in a matrixed organization.

• Familiarity with data governance, metadata management, access control, and regulatory requirements (e.g., GDPR, HIPAA, SOX).

• Excellent leadership, communication, and stakeholder engagement skills.

• Well versed with full stack development & DataOps automation, logging frameworks, and pipeline orchestration tools.

• Strong analytical and problem-solving skills to address complex data challenges.

• Effective communication and interpersonal skills to collaborate with cross-functional teams.

Good-to-Have Skills:

• Data Engineering Management experience in Biotech/Life Sciences/Pharma

• Experience using graph databases such as Stardog or Marklogic or Neo4J or Allegrograph, etc.

Education and Professional Certifications

• Doctorate Degree with 3-5 + years of experience in Computer Science, IT or related field 

• Master’s degree with 10 - 15 + years of experience in Computer Science, IT or related field 

• Bachelor’s degree with 13 - 18 years of experience in Computer Science, IT or related field  

• AWS Certified Data Engineer preferred

• Databricks Certificate preferred

• Scaled Agile SAFe certification preferred

Soft Skills:

• Excellent analytical and troubleshooting skills

• Strong verbal and written communication skills

• Ability to work effectively with global, virtual teams

• High degree of initiative and self-motivation

• Ability to manage multiple priorities successfully

• Team-oriented, with a focus on achieving team goals

• Strong presentation and public speaking skills

EQUAL OPPORTUNITY STATEMENT 

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. 

We will ensure that individuals with disabilities are provided with reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.