Sr. Scientist, Clinical Pharmacology

Senior Scientist – Quantitative Systems Pharmacology (QSP) Modeling

Position Summary

The Senior Scientist, QSP Modeling will develop and apply mechanistic quantitative systems pharmacology models to support drug discovery and development. This role focuses on hands-on model development, integration of biological and clinical data, and generation of insights to guide dose selection, target validation, and clinical strategy.

Key Responsibilities

• Develop, calibrate, and validate mechanistic QSP models to describe disease biology, drug mechanism of action, and PK/PD relationships.
• Integrate diverse data sources (in vitro, in vivo, clinical, omics, literature) into QSP modeling frameworks.
• Perform model-based simulations to support:
• Target and pathway evaluation
• Dose and regimen selection
• Biomarker strategy
• Translational predictions from preclinical to clinical stages
• Collaborate closely with cross-functional teams including Biology, Pharmacology, Clinical Pharmacology, Biomarkers, and Translational Medicine.
• Document model assumptions, structure, qualification, and limitations according to internal and regulatory standards.
• Prepare technical reports, presentations, and visualizations to communicate model insights to project teams.
• Contribute to publications, posters, and internal scientific forums.
• Maintain awareness of emerging QSP methodologies, tools, and best practices.

Required Qualifications

• PhD (or equivalent) in Pharmacology, Systems Biology, Bioengineering, Applied Mathematics, Chemical Engineering, or a related quantitative discipline.
• 2–5 years of experience applying QSP or mechanistic modeling in pharmaceutical or biotech settings (or equivalent postdoctoral + industry experience).

#LI-AB1 #LI-Hybrid

U.S. Pay Range

$131,800.00 - $178,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.